Breymann

Group Leader:
Prof. Dr. Christian Breymann

 

Name of the Institution
Department of Obstetrics
University Hospital Zurich

Street
Frauenklinikstrasse 10

City
8091 Zürich

Phone
+41 (0)44 255 51 34

Fax
+41 (0)44 255 44 30

 

Dr. Matthias Jacob
Dr. Alexander Krafft, MD, research fellow, clinical assistant,
Dr. Michèle Stahel

Main Field of Research, Abstract

FetoMaternal iron metabolism, iron deficiency and anaemia. Differential diagnosis of anaemia in pregnancy using modern haematological laboratory methods (erythrocyte flow cytometry, serum transferrin receptor essay). Therapy of anaemia during pregnancy and postpartum with special emphasis on intravenous iron sucrose and recombinant EPO. Physiology of erythropoietin during pregnancy and lactation. EPO levels in amniotic fluid and cod blood. Pharmacodynamics and – kinetics of rhEPO in pregnancy and lactation. Factors influencing EPO levels in pregnancy, postpartum and perioperatively.
Physiology and pathophysiology of erythropoiesis during pregnancy and lactation with special emphasis on inhibiting inflammatory factors.
Diagnosis and therapy of haemoglobinopathies during pregnancy.
Influence of oxygen on the placental development in a mouse model, including signal pathways of HIF in the placenta.
Cardiovascular tissue enigineering from fetal cells.

Main Fields of Research, Keywords

Perinatal physiology, oxygen, fetal development, anemia, monitoring, tcPo2

Iron, anaemia, erythropoiesis, erythropoietin, pregnancy, postpartum, placenta, oxygen

Special Techniques and Equipment

Automated red cell analyzer (ADVIA) using red cell flow cytometry. Serum transferrin receptor ELISA, serum neopterin ELISA. Molecular diagnostics of haemoglobinopathies (cooperation). Hypoxic mouse chamber (cooperation ETH Zurich).

Education and Training

Weekly research colloquia at the Institute of Perinatal Physiology. Research fellow programs for post doc stipendiates and candidates for doctor thesis. Training opportunities for interested medical and biological scientists.
Special lecture: Feto Maternal haematology

Selected Publications

  1. Breymann C Iron deficiency and anaemia in pregnancy: Modern aspects of diagnosis and therapy. Blood Cells Molecules And Diseases. 29 (3): 506-516, 2002
  2. Kadner A. Hoerstrup SP. Tracy J. Breymann C. Maurus CF. Melnitchouk S. Kadner G. Zünd G. Turina M. Human umbilical cord cells: a new cell source for cardiovascular tissue engineering. Annals of Thoracic Surgery. 74(4):S1422-8, 2002
  3. Perewusnyk G. Huch R. Huch A. Breymann C. Parenteral iron therapy in obstetrics: 8 years experience with iron-sucrose complex. British Journal of Nutrition. 88(1):3-10, 2002
  4. Hoerstrup SP. Kadner A. Breymann C. Maurus CF. Guenter CI. Sodian R. Visjager JF. Zund G. Turina MI. Living, autologous pulmonary artery conduits tissue engineered from human umbilical cord cells. Annals of Thoracic Surgery. 74(1):46-52; 2002 Jul.
  5. Krafft A. Breymann C. Streich J. Huch R. Huch A. Hemoglobin concentration in multiple versus singleton pregnancies--retrospective evidence for physiology not pathology. [Journal Article] European Journal of Obstetrics, Gynecology, & Reproductive Biology. 99(2):184-7, 2001 D
  6. Breymann C. Visca E. Huch R. Huch A. Efficacy and safety of intravenously administered iron sucrose with and without adjuvant recombinant human erythropoietin for the treatment of resistant iron-deficiency anemia during pregnancy. American Journal of Obstetrics & Gynecology. 184(4):662-7, 2001 Mar.
    UI: 11262469
  7. Rohling RG. Zimmermann AP. Breymann C. Intravenous versus oral iron supplementation for preoperative stimulation of hemoglobin synthesis using recombinant human erythropoietin. [Clinical Trial. Journal Article. Randomized Controlled Trial] Journal of Hematotherapy & Stem Cell Research. 9(4):497-500, 2000
  8. Breymann C. Erythropoietin test methods. Best Practice & Research Clinical Endocrinology & Metabolism. 14(1):135-45, 2000
  9. Breymann C. Rohling R. Huch A. Huch R. Intraoperative endogenous erythropoietin levels and changes in intravascular blood volume in healthy humans. Annals of Hematology. 79(4):183-6, 2000
  10. Breymann C. Richter C. Huttner C. Huch R. Huch A. Effectiveness of recombinant erythropoietin and iron sucrose vs. iron therapy only, in patients with postpartum anaemia and blunted erythropoiesis. [Clinical Trial. Journal Article. Randomized Controlled Trial] European Journal of Clinical Investigation. 30(2):154-61, 2000.

Funding

Hartmann Müller Stiftung, Forschungsfond Universität Zürich

URL

(Institution's Address on Internet and, if available, on Intranet)
www.geburtshilfe.usz.ch