Dr. Matthias Jacob
Dr. Alexander Krafft, MD, research fellow, clinical assistant,
Dr. Michèle Stahel
Main Field of Research, Abstract
FetoMaternal iron metabolism, iron deficiency and anaemia.
Differential diagnosis of anaemia in pregnancy using modern
haematological laboratory methods (erythrocyte flow cytometry, serum
transferrin receptor essay). Therapy of anaemia during pregnancy and
postpartum with special emphasis on intravenous iron sucrose and
recombinant EPO. Physiology of erythropoietin during pregnancy and
lactation. EPO levels in amniotic fluid and cod blood. Pharmacodynamics
and – kinetics of rhEPO in pregnancy and lactation. Factors influencing
EPO levels in pregnancy, postpartum and perioperatively.
and pathophysiology of erythropoiesis during pregnancy and lactation
with special emphasis on inhibiting inflammatory factors.
Diagnosis and therapy of haemoglobinopathies during pregnancy.
Influence of oxygen on the placental development in a mouse model, including signal pathways of HIF in the placenta.
Cardiovascular tissue enigineering from fetal cells.
Main Fields of Research, Keywords
Perinatal physiology, oxygen, fetal development, anemia, monitoring, tcPo2
Iron, anaemia, erythropoiesis, erythropoietin, pregnancy, postpartum, placenta, oxygen
Special Techniques and Equipment
Automated red cell analyzer (ADVIA) using red cell flow cytometry.
Serum transferrin receptor ELISA, serum neopterin ELISA. Molecular
diagnostics of haemoglobinopathies (cooperation). Hypoxic mouse chamber
(cooperation ETH Zurich).
Education and Training
Weekly research colloquia at the Institute of Perinatal Physiology.
Research fellow programs for post doc stipendiates and candidates for
doctor thesis. Training opportunities for interested medical and
Special lecture: Feto Maternal haematology